Odd Mushroom: The speed down from the Virus does not stack with the Odd Mushroom if both are collected, only a total of -0.1 applies. Invulnerability: Contact while invincible poisons enemies. Gnawed Leaf and The Virus can still work if Isaac has a short-range orbital such as Cube of Meat or Ball of Bandages, as it will kill enemies pushing against Isaac that are not taking poison damage while still dropping Black Hearts. Enemies won't start taking poison damage if they are pushing up against Isaac The Virus will be constantly trying to apply poison and refreshing the ticks where poison damage would occur. Although Stonies and Shopkeepers can't be visibly poisoned, they still can drop Black Hearts if destroyed after being touched. With Skatole, Hives and Swarmers will constantly spawn normal Flies, meaning they can be endless sources of Black Hearts. Black flies, Mulligans, and Hosts are the most common enemies this can be applied to. If an enemy doesn't do contact damage, The Virus can safely be applied to it for more chances at black hearts. The item's effect doesn't extend to poison tears. The black heart is only dropped if the poison was caused by The Virus. If you dont want your game spoiled for you, please hit the back button immediately Yes, The Binding of Isaac The Binding of Isaac is a randomly generated action RPG shooter with heavy Rogue-like elements. 
Collecting three items from this set will transform Isaac into a buff berserker. This wiki contains information about the new The Binding of Isaac : Rebirth.
This is not applied until the next time Isaac's speed stat is updated. The Binding of Isaac: Afterbirth adds an additional 8 transformations to the base game This is a large amount compared to the original two found in Rebirth. Enemies who are killed after they have been inflicted with this type of poison have a 20% chance to drop Black Hearts. Lets Isaac deal 24 contact damage per tick on top of applying poison (48 damage per second). The poison can be continuously applied to bosses, which normally are immune to status effects for a brief time after being inflicted with one. The poison lasts for 6-7 ticks and deals damage equal to (0.2*HeartContainers^2) + 2, where HeartContainers is the total number of heart containers and bone hearts Isaac has. The poison deals Isaac's damage per tick (1.5x Isaac's damage per second) and lasts for 6 ticks for normal enemies and 3 ticks for bosses. The poison deals Isaac's damage per tick (1.5x Isaac's damage per second) and lasts for 2-3 ticks. The Binding of Isaac: Rebirth is the ultimate of remakes with an all-new highly efficient game engine (expect 60fps on most PCs), all-new hand-drawn pixel style artwork, highly polished visual effects, all-new soundtrack and audio by the the sexy Ridiculon duo Matthias Bossi + Jon Evans. The poison deals 2 damage per tick (3 damage per second) and lasts for 2-3 ticks. Inflicts poison on enemies who make contact with Isaac.
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